Gallery

Conformations of Major Platelet Integrin αIIbβ3 Cytoplasmic Tails

         αIIbβ3 Complex AlphaIIb-beta3 complex

1M8O

Platelet Integrin αIIbβ3 Cytoplasmic Domain 

Vinogradova, O., Velyvis, A., Velyviene, A., Hu, B., Haas, T.A., Plow, E.F., Qin, J.(2002) Cell 110

Released: 9/18/2002
Method: Solution NMR
Residue Count: 67

 

  αIIb Subunit  

1DPK

Solution Structure of the Cytoplasmic Domain of the Integrin αIIb Subunit

Vinogradova, O., Haas, T., Plow, E.F., Qin, J.

a2b_mut

(2000) Proc Natl Acad Sci U S A 97

Released: 2/28/2000
Method: Solution NMR
Residue Count: 20

1DPQ

Solution Structure of the Cytoplasmic Domain of the Constitutively Active Mutant of the Integrin αIIb Subunit

Vinogradova, O., Haas, T., Plow, E.F., Qin, J.(2000) Proc Natl Acad Sci U S A 97

Released: 2/28/2000
Method: Solution NMR
Residue Count: 20

1S4W

a_b_mic

NMR Structure of the Cytoplasmic Domain of Integrin αIIb in DPC micelles

Vinogradova, O., Vaynberg, J., Kong, X., Haas, T.A., Plow, E.F., Qin, J.

(2004) Proc Natl Acad Sci U S A 101

Released: 3/9/2004
Method: Solution NMR
Residue Count: 20

                   β3 Subunit

1S4X

NMR Structure of the integrin β3 cytoplasmic domain in DPC micelles

Vinogradova, O., Vaynberg, J., Kong, X., Haas, T.A., Plow, E.F., Qin, J.

(2004) Proc Natl Acad Sci U S A 101

Released: 3/9/2004
Method: Solution NMR
Residue Count: 67

2LJD phosphorylated betta3 in micelles

Monophosphorylated (747pY) β3 Integrin Cytoplasmic Tail under Membrane Mimetic Conditions

Deshmukh, L., Meller, N., Alder, N., Byzova, T., Vinogradova, O.

(2011) J Biol Chem 286

Released: 10/5/2011
Method: Solution NMR
Residue Count: 67

2LJE

Biphosphorylated (747pY, 759pY) β3 Integrin Cytoplasmic Tail under Membrane Mimetic Conditions

Deshmukh, L., Meller, N., Alder, N., Byzova, T., Vinogradova, O.

(2011) J Biol Chem 286

Released: 10/5/2011
Method: Solution NMR
Residue Count: 67

2LJF monophosphorylated beta3

Monophosphorylated (747pY) β3 Integrin Cytoplasmic Tail under Aqueous Conditions

Deshmukh, L., Meller, N., Alder, N., Byzova, T., Vinogradova, O.

(2011) J Biol Chem 286

Released: 10/5/2011
Method: Solution NMR
Residue Count: 67

 

Proteins Associated with Integrin Signaling Pathway and Protein-Integrin Complexes

Selemin-integrin complex

 Skelemin

4V10  

Skelemin Association with αIIbβ3 Integrin: A Structural Model

Gorbatyuk, V., Nguyen, K., Podolnikova, N.P., Deshmukh, L., Lin, X., Ugarova, T.P., Vinogradova, O.

(2014) Biochemistry 53

Released: 10/8/2014
Method: Solution NMR/Docking
Residue Count: 231

2JTD

Skelemin Immunoglobulin C2 like Domain 4

Deshmukh, L., Tyukhtenko, S., Liu, J., Fox, J.E., Qin, J., Vinogradova, O.

(2007) J Biol Chem 282

Released: 9/4/2007
Method: Solution NMR
Residue Count: 142

Src KinaseSrc SH3 domain complex with integrin

Structural Insights into the Recognition of β3 Integrin Cytoplasmic Tail by SH3 Domain of Src Kinase

Katyal, P., Puthenveetil, R., Vinogradova, O.

(2013) Protein Science 22

Method: Solution NMR/Docking

 

Shc Adaptor Protein Shc PTB domain at membrane interface

 

2L1C

Shc-PTB:Biphosphorylated Integrin β3 Cytoplasmic Tail Complex 

Deshmukh, L., Gorbatyuk, V., Vinogradova, O.

(2010) J Biol Chem 285

Released: 8/18/2010
Method: Solution NMR
Residue Count: 238

 

 

Other Projects

 L1-CAM

Characterization of the Neuron-Specific L1-CAM Cytoplasmic Tail: Naturally Disordered in Solution It Exercises Different Binding Modes for Different Adaptor Proteins

Tyukhtenko, S., Deshmukh, L., Kumar, V., Lary, J., Cole, J., Lemmon, V.,

Vinogradova, O.

(2008) Biochemistry 47

Method: Solution NMR
Residue Count: 114

DP00666: Neural cell adhesion molecule L1 [Isoform 1]

Database of Protein Disorder – DisProt: http://www.disprot.org/index.php

 Human Cannabinoid Receptor1

2KOE

Human Cannabinoid Receptor 1 - Helix 7/8 Peptide

Tyukhtenko, S., Tiburu, E.K., Deshmukh, L., Vinogradova, O., Janero, D.R., Makriyannis, A.

(2009) Biochem Biophys Res Commun 390

Released: 10/6/2009
Method: Solution NMR
Residue Count: 40

 2KI9

Human Cannabinoid Receptor-2 Helix 6

Tiburu, E.K., Tyukhtenko, S., Deshmukh, L., Vinogradova, O., Janero, D.R., Makriyannis, A.

(2009) Biochem Biophys Res Commun 384

Released: 5/12/2009
Method: Solution NMR
Residue Count: 33

Dihydrofolate Reductase (DHPR)

2KGKDHFR structure

Solution structure of Bacillus anthracis dihydrofolate reductase 

Beierlein, J.M., Deshmukh, L., Frey, K.M., Vinogradova, O., Anderson, A.C.

(2009) Biochemistry 48

Released: 5/12/2009
Method: Solution NMR
Residue Count: 172

Penta-Peptide Calpain Inhibitor

NMR Structural Characterization of the Penta-Peptide Calpain Inhibitor 

Ligand binding pocket of calmodulin domain

Deshmukh, L., Wu, L., Guttmann, R.P., Vinogradova,O.

(2009) FEBS Letters 583

Method: Solution NMR/Docking
Residue Count: 5